Its exactly as you say Scott,
I also monitor build for the first 4 layers, and then shut the door.
Any "floaters" will interfere with model quality. Small glitches will not likely cause issues, but large ones will. This is a limitation of Ember's separation system but personally I am fine with that because it is the most stress free release method, allowing for very fine detail.
What I m not a fan of is Print Studio's support generation algorithm and methods, maybe because I did not tweak it to my liking. That's why I create my supports in CAD, full manually. I use draft angle analysis to determine the areas requiring supports. Its time consuming, and I might miss something, but it gives me the control I need. After all I m the one who will remove the supports, so I need to place them in accessible areas.